前言：目的观察补肾、健脾、活血中药对溶血性贫血大鼠造血及红细胞生成素(GM-CSF)、粒-巨噬细胞集落刺激因子(EPO)、白介素-2(IL-2)的影响。方法采用乙酰苯肼造成大鼠溶血性贫血,对造模成功者分别给予补肾药、健脾药、活血药、活髓片、活髓片与活髓膏合用,共13天。用放射免疫法检测血中GM- CSF、EPO及IL-2。结果健脾组大鼠存活率及血红蛋白均最高；对GM-CSF的影响,补肾组、健脾组及合治组高于正常组、对照组、活血组(P＜0。05)；造模大鼠各组IL-2均高于正常组,实验各组之间差异无显著性(P＞0。05)；健脾组EPO最高,高于补肾组、活血组及活髓组(P＜0。05),各用药组与对照组比较差异有显著性(P＜0。05,P＜0。01)。结论补肾、健脾、活血中药促进造血的机制与环节有所不同。
Objective To investigate the effect of Chinese herbs for tonifying Shen,invigorating Pi and pro- moting blood circulation on hematopoesis,granulocyte-macrophage colony stimulating factor(GM-CSF),erythro- poietin(EPO)and interleukin-2(IL-2)in rats with hemolytic anemia(HA).Methods The HA rats model were established by using acetyl phenyl hydrazine(APH),and the successful model rats were treated with Chinese herbs for tonifying Shen,invigorating Pi,promoting blood circulation,Huoxue tablet,Huoxue tablet combi...
文献名称 补肾、健脾、活血中药及活髓片、活髓膏对溶血性贫血大鼠造血及GM-CSF、EPO、IL-2的影响
Article Name
英文(英语)翻译 Effect of Chinese Herbs for Touifying Shen,Invigorating Pi and Promoting Blood Circulation and Huosui Tablet,Huosul Onintment on Hematopoiesis,GM-SCF,EPO and IL-2 in Rats with Hemolytic Anemia;
作者 曹克俭;
Author CAO Ke-jian College of Traditional Chinese Medicine;Hongkong University;
作者单位
Author Agencies 香港大学中医药学院;
文献出处
Article From 中国科学院上海冶金研究所; 材料物理与化学(专业) 博士论文 2000年度
关键词 补肾、健脾、活血中药; 溶血性贫血; 血红蛋白; 红细胞生成素; 粒-巨噬细胞集落刺激因子; 白介素-2;
Keywords Chinese herbs for tonifying Shen;invigorating Pi and promoting blood circulation;hemolytic anemia;hemoglobin;granulocyte-macrophage colony stimulating factor;erythropoietin;interleukin-2;

论补肾健脾活血中药治疗原发性骨质疏松症的作用机制
补肾健脾活血中药复方对D-半乳糖脑衰老小鼠海马皮质一氧化氮合酶、Na~+-K~+-ATP酶的影响
归芪方合苯那普利对糖尿病大鼠肾组织转化生长因子β_1的影响
桑精胶囊改善2型糖尿病大鼠胰岛素抵抗及其分子机制的研究
木芙蓉叶有效组分对大鼠肾缺血再灌注损伤中TNF-α的影响
狼疮方对慢性GVHD狼疮样肾炎小鼠模型的作用
决明子对实验性大鼠糖尿病肾病疗效观察
中药肾华对慢性肾炎大鼠肾组织Stat3表达及活化的影响
肝康Ⅱ号抗肝纤维化的实验研究
中药丹芍化纤胶囊对肝纤维化大鼠金属蛋白酶组织抑制因子-1表达的影响